|
Child Development Disorders, Pervasive
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells.
|
22899010 |
2012 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
IMP2 (insulin-like growth factor-II mRNA binding protein 2) is an oncofetal protein that is aberrantly expressed in several types of cancer.
|
17426251 |
2007 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
p62/IMP2 is an oncofetal protein that is overexpressed in several types of cancer, and is a member of the family of insulin-like growth factor 2 mRNA binding proteins.
|
26416451 |
2015 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
IMP2 stabilization of <i>HMGA1</i> mRNA plus IMP2 stimulated IGF2 production synergistically drive cancer cell proliferation and account for IMP2's tumor promoting action.
|
28753127 |
2017 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Adult expression of IMP2 is often associated with several types of disease and cancer.
|
29859241 |
2018 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
IMP2 (insulin-like growth factor-II mRNA binding protein 2) is an oncofetal protein that is aberrantly expressed in several types of cancer.
|
17426251 |
2007 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
IMP2 stabilization of <i>HMGA1</i> mRNA plus IMP2 stimulated IGF2 production synergistically drive cancer cell proliferation and account for IMP2's tumor promoting action.
|
28753127 |
2017 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
p62/IMP2 is an oncofetal protein that is overexpressed in several types of cancer, and is a member of the family of insulin-like growth factor 2 mRNA binding proteins.
|
26416451 |
2015 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells.
|
22899010 |
2012 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Adult expression of IMP2 is often associated with several types of disease and cancer.
|
29859241 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Molecular classification of IMP2-overexpressing tumors revealed an aggressive phenotype.
|
26426686 |
2015 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
IMP2 immunoreactivity was found in 74.3% of the tumor samples on TMA, of which 14.0% showed strong and 86.0% low staining intensity.
|
29163784 |
2017 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
IMP2 stabilization of <i>HMGA1</i> mRNA plus IMP2 stimulated IGF2 production synergistically drive cancer cell proliferation and account for IMP2's tumor promoting action.
|
28753127 |
2017 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
To understand the autoimmune response and immunogenicity of a tumour-associated antigen (TAA) and IGF2 mRNA-binding protein (IMP2/62) in colon cancer, autoantibody to this TAA was evaluated by enzyme-linked immunosorbent assay (ELISA), Western blotting and indirect immunofluorescence assay in sera from patients with colon cancer.
|
23421499 |
2013 |
|
Pervasive Development Disorder
|
0.030 |
Biomarker
|
group |
BEFREE |
Genomic Deletion Involving the IMMP2L Gene in Two Cases of Autism Spectrum Disorder.
|
29788020 |
2018 |
|
Pervasive Development Disorder
|
0.030 |
Biomarker
|
group |
BEFREE |
First behavioural assessment of a novel Immp2l knockdown mouse model with relevance for Gilles de la Tourette syndrome and Autism spectrum disorder.
|
31233820 |
2019 |
|
Pervasive Development Disorder
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Here we genotyped 100 trio families with an index proband with autism spectrum disorder in Han Chinese population and found three cases with rare exonic IMMP2L deletions.
|
29152845 |
2018 |
|
Adenoma
|
0.010 |
Biomarker
|
group |
BEFREE |
The result has showed that there has a relatively higher frequency of autoantibody response to IMP2/p62 in colon cancer (23.4%, 15/64) compared to patients with colonic adenomas (4.8%, 2/42) and normal individuals (2.9%, 1/34).
|
23421499 |
2013 |
|
Behavior Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Our data would indicate that deletions involving the IMMP2L gene may contribute to the development of a subgroup of cognitive/behavioral disorders.
|
29788020 |
2018 |
|
Septicaemia due to gram-negative organism, unspecified
|
0.010 |
Biomarker
|
group |
BEFREE |
In secondary analyses, SNPs for ELMO1, IRAK2 (Gram-positive sepsis), RALA, IMMP2L (Gram-negative sepsis) and PIEZO2 (fungal sepsis) met target significance levels.
|
28283553 |
2017 |
|
Neurodevelopmental Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
IMMP2L, the gene encoding the inner mitochondrial membrane peptidase subunit 2-like protein, has been reported as a candidate gene for Tourette syndrome, autism spectrum disorder (ASD) and additional neurodevelopmental disorders.
|
29152845 |
2018 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
|
31374203 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Together, our findings suggest that IMP2 and IMP3 partially determine the characteristic phenotype and synergistically promote the metastasis of TNBC by downregulating PR.
|
29217458 |
2018 |
|
Tumor Progression
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Besides tumor initiation, IMP2 also seemed to have an impact on tumor progression.
|
31261900 |
2019 |